Adipose Stem Cell Center

Yen Chih Lin, PhD

Post-Doctoral Fellow

I received my PhD degree with the Animal Science Department of National Chung-Hsing University in Taiwan. My main area of interest is the application of stem cells in tissue engineering. The proposed topic of my PhD dissertation was to evaluate the use of copolymer scaffold produced as natural by-products to mimic target matrices. I have obtained excellent results of in vitro cell culture of the 3D scaffold and in vivo cartilage tissue engineering for treatment of cartilage defects in animal models (rat and swine). In the mean time, I also studied the relationship between adipose stem cell and synthetic biomaterials. Moreover, I have examined not only bio-polymer scaffold processes, but also characterizations of different materials and stem cells.

Current Research Projects:

1. Adipose-derived stem cell and in vitro bioreactor technologies.
2. Polymer guides and microspheres for long-term neurotrophic growth factors applied in long gap nerve repair. 

Publications:

1. Lin, Y. C., F.-J. Tan, K. G. Marra, S. S. Jan, D. C. Liu. 2010. Evaluation of pepsin digestion of atelocollagen from different chicken combs at low temperature. Food Chemistry, In Press.
2. Lin, Y. C., C. A. Brayfield, J. C. Gerlach, J. P. Rubin and K. G. Marra. 2009. Peptide modification of polyethersulfone surfaces to improve adipose-derived stem cell adhesion. Acta Biomaterialia, 5: 1416-1424
3. Lin Y. C., F. J. Tan, K. G. Marra, S. S. Jan, and D. C. Liu. 2009. Synthesis and characterization of collagen/hyaluronan/chitosan composite sponges for potential biomedical applications. Acta Biomaterialia 5: 2591-2600.
4. Lin Y. C., F. J. Tan, K. G. Marra, and D. C. Liu. 2009. Evaluation of pepsin digestion of atelocollagen from different chicken combs at low temperature. Food Chemistry. (In Press)
5. Kokai, L. E., Y. C. Lin, N. M. Oyster and K. G. Marra. 2009. Diffusion of soluble factors through degradable polymer nerve guides: Controlling manufacturing parameters Acta Biomaterialia. 5: 2540-2550.
6. Miljkovic, N.D.; Y. C. Lin, M. Cherubino, D. Minteer, K. G. Marra. 2009. A Novel Injectable Hydrogel in Combination with a Surgical Sealant in a Rat Osteochondral Defect Model,” Knee Surgery, Sports Traumatology, Arthroscopy. (In Press)
7. Liu, D. C., R. T. Tsau, Y. C. Lin, S. S. Jan and F. J. Tan. 2009. Effect of various levels of rosemary or Chinese mahogany on the quality of fresh chicken sausage during refrigerated storage. Food Chemistry. 117: 106-113.
8. Lin, Y. C. and D. C. Liu. 2004. Study of the Activity of Angiotensin Converting Enzyme Inhibitors Derived from Chick Embryos. J. Chinese Soci. Ani. Sci. 33: 284.
9. Lin, Y. C. and D. C. Liu. 2009. In vitro evaluation of collagen-hyaluronan-chitosan scaffold for cartilage tissue engineering. Biomaterial_Asia 2009 Conference. (Hong Kong, China).
10. Lin, Y. C., C. A. Brayfield, J. P. Rubin and K. G. Marra. 2008. Optimal Concentrations for Covalent Arg-Gly-Asp Peptide Modifcation of Polyethersulfone Surfaces for Improved Adipose-derived Stem Cell Adhesion MIRM 2008. (Pittsburgh, USA).
11. Lin, Y. C., C. A. Brayfield, J. C. Gerlach, J. P. Rubin and K. G. Marra 2007. Modification of Polyethersulfone Surfaces to Improve Adipose Stem Cell Adhesion. MIRM 2007. (Pittsburgh, USA).
12. Lin, Y. C. and D. C. Liu. 2007. Studies of Collagen/ hyaluronan/ chitosan tri-copolymer sponge as the scaffold in cartilage tissue engineering. Tissue Engineering and Regenerative Medicine International Society. (Toronto, Canda)
13. Lin, Y. C. and D. C. Liu. 2006. Evaluation of biocompatibility of the porous scaffolds which manufactured by collagen/ hyaluronic acid from different kinds of chicken combs. 9^th Congress of Engineering Technology and medical application. (Taichung, Taiwan).
14. Tan, F. J., C. C. Fang, C. Y. Cheng, Y. Y. Tseng, Y. C. Lin and D.C. Liu. 2005. Influence of preslaughter holding on the bacterial quality of markrt hogs and carcass. 52^th International Congress of Meat Science and Technology. (Dublin, Ireland).

Personal Interests:

My personal interests are photography and playing Chinese violin (erhu fiddle).